Not easily, I'd imagine. The code is currently written for Microsoft.NET and DirectX 9, neither of which have ports to the DS, so somebody would have to either rewrite SGDK2 or Microsoft.NET, the first being a daunting task, the second, near impossible. And even if one did, they would also have to rewrite SGDK2 to use the built-in graphics mode for the DS instead of DirectX.
